Chems have been present in the Fallout franchise for a long time, and Fallout 4 added a new array of chems for players to use during combat and outside of combat situations. The chems in Fallout 4 grant many different effects, including slowing down time and giving the player a boost to their SPECIAL stats, among many other effects that are useful.
The chems in Fallout 4 are all very powerful; however, some of them are better than others. There are also some chems that are very difficult to obtain either because they require a lot of ingredients to craft them or because they are only found rarely throughout the world.
10 Med-X
Med-X is a great chem, and it is widely used in the wasteland of Fallout 4. Med-X grants the player a 25 damage resistance buff which, although it may not seem like a lot, it is common enough that this chem can be used regularly and become a very useful asset for the Sole Survivor.
Although 25 damage resistance isn’t the end-all-be-all in a fight, it will help determine who the victor is during a tough battle.
9 Psycho Jet
Psycho Jet isn’t quite as common as Med-X; however, it is one of the most powerful chems in the wasteland. Psycho Jet grants the player extra AP, 15 seconds of slow down time, a 25% damage buff, and a 25% damage resistance buff.
Every player that wants to be a powerful time-manipulator should always keep a few Psycho Jet in their inventory because this chem will be invaluable in a situation where time needs to be slowed so that the player can think more clearly about their actions.
8 Grape Mentats
Grape Mentats have two effects, lowering vendor prices by 10% and granting the player five extra Charisma for a limited duration of time. Although Grape Mentats don’t last for a very long time, they are very useful for players that aren’t focusing on Charisma since they can be used right before a speech check so that the player can pass it.
For players that aren’t focusing on Charisma as a stat, at least one Grape Mentat should always be in the player’s inventory at all times.
7 Buffjet
Buffjet has a whole host of effects; however, most players consider the most useful of them to be slowing down time for 15 seconds and granting the player three extra Endurance and Strength points. This is a wonderful combination for melee builds since it allows the player to do much more damage in a short period of time.
Buffjet also grants the player extra health and AP, which means that they will be able to leap into more dangerous situations and take risks while this chem is activated.
6 Fury
Fury is another useful chem for players that are using a melee build, as its effects boost the player’s damage resistance by 25% and grant 50% more damage with melee weapons.
Both of these effects are very useful for a melee character that has to initiate close combat to deal any damage, and since Fury is a rare chem, it is worth saving it for an important occasion such as the final battle with the Institute or the Brotherhood of Steel.
5 Psychbuff
Psychobuff grants the player 65 extra health, three extra points of Strength and three extra points of Endurance, while also giving them a damage resistance buff. Psychobuff isn’t too difficult to craft as a player only needs a Buffout and a Psycho to complete this recipe.
Psychobuff is a strong chem, and much like some of the other chems in Fallout 4, it is perfect to use with a melee build that will be in close proximity with an enemy while attacking them.
4 Overdrive
Overdrive gives the player the ability to deal 25% more damage to enemies and also have a 25% critical rate in VATS. For this reason, Overdrive is the best chem for a player that uses VATS as a main component in their build.
Unfortunately, there aren’t many other chems in the game that focus specifically on VATS combat; however, Overdrive is the perfect chem for a player with this type of build since it grants extra critical hit chance.
3 Orange Mentats
Orange Mentats are another great version of Mentats, but in this variant, they offer abilities that are more useful for a stealth sniper build. Orange Mentats give the player a boost to their Perception stat; it also grants a 10% extra hit chance to every limb in VATS.
Any player that is using a sniper will be able to benefit from these effects since VATS is usually a key component in those builds. It is worth obtaining Orange Mentats for dangerous sniper situations so that the player will always be prepared if they don’t have enough of a chance to hit a headshot in combat.
2 X-Cell
X-Cell is one of the rarest chems in Fallout 4; however, it is also one of the most useful. X-Cell grants the player an extra two points to every special stat, which is great for any kind of build that the player may be using.
X-Cell is an especially useful chem if the player is about to walk into a situation where they feel they may not be able to win since it grants a buff to every stat in the game.
1 Ultra Jet
Ultra Jet has a very similar effect to other variants of Jet in the game; it slows time for 15 seconds so that the player can make more strategic decisions.
However, Ultra Jet also has a secondary effect, granting the player 100 extra action points for 15 seconds. These action points can be used for many different things, such as attacking in VATS or sprinting towards an enemy. Overall, Ultra Jet is a great chem, and every type of build in Fallout 4 can benefit from using it.
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